ChemicalBook CAS DataBase List Indole-5-carboxaldehyde

Indole-5-carboxaldehyde synthesis

12synthesis methods

Product Name:Indole-5-carboxaldehyde
CAS Number:1196-69-6
Molecular formula:C9H7NO
Molecular Weight:145.16

120-72-9 Synthesis

120-72-9
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$6.00/25g

109-94-4 Synthesis

109-94-4
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$10.00/10g

1196-69-6
300 suppliers
$9.00/1g

Yield:1196-69-6 95%

Reaction Conditions:

Stage #1:indole;formic acid ethyl ester at 35 - 45; for 1 h;Inert atmosphere;
Stage #2: with zinc(II) chloride at 45 - 55; for 12 h;Inert atmosphere;Reagent/catalyst;

Steps:

1-4 Example 1
At room temperature, 500 ml of ethyl formate and 117 g of indole were added to the reaction flask under the protection of nitrogen.The mixture was warmed to 35-45 ° C and stirred for 1 h.At room temperature, add 272g of zinc chloride under the reaction flask.Heated to 45-55 degrees and refluxed for 12h,Filtrate while hot, reduce the temperature to -10 degrees, and filter to obtain 140 g of 5-aldehyde indole as a pale yellow solid.Yield: 95%, purity: 99.98%.

References:

Suzhou Yongjian Bio-pharmaceutical Co., Ltd.;Gao Yuan;Cui Huaijie;Zong Yanglei CN110734390, 2020, A Location in patent:Paragraph 0011; 0016-0023