1-hydroxycyclohexyl-(4-methylphenyl)-methanone synthesis
- Product Name:1-hydroxycyclohexyl-(4-methylphenyl)-methanone
- CAS Number:133047-88-8
- Molecular formula:C14H18O2
- Molecular Weight:218.29
2789-44-8
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Yield:133047-88-8 36 g
Reaction Conditions:
with hydrogen bromide in dimethyl sulfoxide at 110; for 18 h;
Steps:
2
42.2 g (0.21 mol) of cyclohexyl-(4-methylphenyl)methanone was dissolved in 253 ml of dimethyl sulfoxide and stirred at room temperature.Adding a mass fraction of 48% hydrobromic acid 3.53 g (0.021 mol), heating to 110 ° C, refluxing for 18 h,The reaction was confirmed by HPLC, and the content of 1-hydroxycyclohexyl (4-methylphenyl)methanone was 89.4%.The reaction was stopped, and dimethyl sulfoxide was recycled by distillation under reduced pressure.52 g of a brown gum was obtained, crystallized to give a pale brown solid (38.5 g), which was again recrystallized to give a white solid, 36 g, content: 99.1%, yield 7.86 %.
References:
CN109369406,2019,A Location in patent:Paragraph 0021; 0022
74-87-3
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84682-27-9
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