ChemicalBook CAS DataBase List 1-Indanecarboxylic acid

1-Indanecarboxylic acid synthesis

11synthesis methods

Product Name:1-Indanecarboxylic acid
CAS Number:14381-42-1
Molecular formula:C10H10O2
Molecular Weight:162.19

29427-69-8
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14381-42-1
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Yield:14381-42-1 95%

Reaction Conditions:

with hydrogen;palladium on activated charcoal in methanol at 20; under 2844.39 Torr; for 18 h;

Steps:

124.124a

Example 124; N-(4-(3-(((3-chloro-4-(methyloxy)phenyl)amino)carbonyl)phenyl)-1,3-thiazol-2-yl)-2,3-dihydro-1H-indene-1-carboxamide; (124a) A MeOH (1 mL) solution of 3-oxo-indancarboxylic acid (85.5 mg, 0.485 mmol) was mixed with Pd/C (16.5 mg) and hydrogenated at room temperature under 55 psi H₂pressure for 18 h. The crude mixture was filtered and concentrated to give 1-indanecarboxylic acid (74.4 mg, 95%). MS Found: (M-H)-=161.

References:

US2007/185056,2007,A1 Location in patent:Page/Page column 51

201230-82-2 Synthesis