1-(isoquinolin-5-yl)ethanone synthesis
- Product Name:1-(isoquinolin-5-yl)ethanone
- CAS Number:54415-44-0
- Molecular formula:C11H9NO
- Molecular Weight:171.2
1204598-85-5
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54415-44-0
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Yield:54415-44-0 98%
Reaction Conditions:
with Dess-Martin periodane in dichloromethane at 20; for 18 h;Inert atmosphere;
Steps:
163.2 Step 2: l-(Isocwinolin-5-yl)ethanone (163.3)
[00821] Dess-Martin reagent (2.74 g, 6.45 mmol) was added to a stirred solution of 163.2 (860 mg, 4.96 mmol) in DCM (15 mL) and the resulting solution was reacted under magnetic stirring at r.t. for 18 h. The whitish suspension thus obtained was poured into DCM (50 mL), then washed with H2O (2 x 30 mL) and brine (30 mL). The combined organic layers were dried over anhydrous Na2SC>4, and evaporated to dryness. Purification by flash chromatography (DCM/MeOH, from 100% DCM to 95:5 v/v DCM/MeOH) gave the desired intermediate 163.3 (835 mg, 4.88 mmol). Yield: 98%. MS-ESI(+) m/z: 172.3 (M+H).
References:
WO2021/170658,2021,A1 Location in patent:Paragraph 00821
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