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ChemicalBook CAS DataBase List 1-M-TOLYL-5-TRIFLUOROMETHYL-PYRROLIDIN-2-ONE
1224599-67-0

1-M-TOLYL-5-TRIFLUOROMETHYL-PYRROLIDIN-2-ONE synthesis

1synthesis methods
1224599-55-6 Synthesis
Methyl 5,5,5-trifluoro-4-(M-tolylaMino)pentanoate

1224599-55-6
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1-M-TOLYL-5-TRIFLUOROMETHYL-PYRROLIDIN-2-ONE

1224599-67-0
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Yield:1224599-67-0 85%

Reaction Conditions:

with sodium hydride in tetrahydrofuran at 20; for 2 h;Inert atmosphere;

References:

Wan, Wen;Hou, Jie;Jiang, Haizhen;Yuan, Zongqian;Goubin, Ma.;Zhao, Gang;Hao, Jian [European Journal of Organic Chemistry,2010,# 9,p. 1778 - 1786] Location in patent:experimental part