Methyl 5,5,5-trifluoro-4-(M-tolylaMino)pentanoate synthesis
- Product Name:Methyl 5,5,5-trifluoro-4-(M-tolylaMino)pentanoate
- CAS Number:1224599-55-6
- Molecular formula:C13H16F3NO2
- Molecular Weight:275.27
22581-31-3
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108-44-1
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$9.00/1g
![1-Pentanol, 5,5,5-trifluoro-4-[(3-methylphenyl)amino]-](/CAS/20210305/GIF/1224599-64-7.gif)
1224599-64-7
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1224599-55-6
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Yield:1224599-55-6 55% ，1224599-64-7 19%
Reaction Conditions:
Stage #1: methyl 5,5,5-trifluoro-4-oxopentanoate;1-amino-3-methylbenzenewith toluene-4-sulfonic acid in toluene;Inert atmosphere;Reflux;
Stage #2: with sodium tetrahydroborate in methanol at 25;Inert atmosphere;
References:
Wan, Wen;Hou, Jie;Jiang, Haizhen;Yuan, Zongqian;Goubin, Ma.;Zhao, Gang;Hao, Jian [European Journal of Organic Chemistry,2010,# 9,p. 1778 - 1786] Location in patent:experimental part