1-METHOXY-4-(METHYLTHIO)BENZENE synthesis
- Product Name:1-METHOXY-4-(METHYLTHIO)BENZENE
- CAS Number:1879-16-9
- Molecular formula:C8H10OS
- Molecular Weight:154.23
624-92-0
350 suppliers
$20.62/5 mL
696-62-8
350 suppliers
$5.00/1g
1879-16-9
122 suppliers
$10.00/1g
Yield:1879-16-9 78%
Reaction Conditions:
with tetrabutylammomium bromide;copper(II) acetate monohydrate;potassium hydroxide in water at 100; for 12 h;Catalytic behavior;Sealed tube;Reagent/catalyst;Temperature;
Steps:
(Het)aryl Methyl Sulfides; General Procedure
General procedure: A 25-mL sealable tube was charged with the appropriate aryliodide or bromide (1.0 mmol), dimethyl disulfide (1.2 mmol),Cu(OAc)2·H2O (0.1 mmol), KOH (2.0 mmol), TBAB (0.05 mmol),and H2O (2.0 mL). The mixture was stirred at 100 °C (130 °C forbromides) for 12 h under air then cooled to r.t. The mixture wasdiluted with H2O (5 mL) and extracted with EtOAc (4 × 10 mL).The extracts were combined, washed with brine (3 × 10 mL),dried (MgSO4), filtered, and concentrated. The residue was purifiedby chromatography [silica gel, EtOAc–hexane (1:30 to1:100)].
References:
Wang, Ying-Yu;Wu, Xiang-Mei;Yang, Ming-Hua [Synlett,2020] Location in patent:supporting information
624-92-0
350 suppliers
$20.62/5 mL
104-94-9
497 suppliers
$9.00/1g
1879-16-9
122 suppliers
$10.00/1g
3517-99-5
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1879-16-9
122 suppliers
$10.00/1g
696-62-8
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$5.00/1g
67-68-5
1319 suppliers
$15.00/100g
1879-16-9
122 suppliers
$10.00/1g
93-58-3
507 suppliers
$13.50/100 mL
696-62-8
350 suppliers
$5.00/1g
1879-16-9
122 suppliers
$10.00/1g