1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLIC ACID synthesis
- Product Name:1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBOXYLIC ACID
- CAS Number:10250-64-3
- Molecular formula:C11H10N2O2
- Molecular Weight:202.21
10250-63-2
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10250-64-3
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Yield: 93.1%
Reaction Conditions:
with sodium hydroxide in methanol at 20; for 2 h;
Steps:
8.2 Step2: Preparation of Compound 1-3
To a solution of 1-2 (247.5 mg, 1.1 mmol) in MeOH (5 mL) was added sodium hydroxide solution (10 mL, 4 M). The reaction mixture was stirred at room temperature for 2 hours and concentrated under reduced pressure to remove MeOH. The aqueous phase was acidified with aqueous HCl (1 M) till pH=3 and the mixture was extracted with EtOAc, dried with anhydrous Na2SO4, filtered and concentrated to give the crude product. The crude product was purified by silica gel chromatography eluted to give product 1-3 (207.0 mg, 93.1%). MS m/z [ESI]: 203.1 [M+1].
References:
SUZHOU SINOVENT PHARMACEUTICALS CO., LTD.;WANG, Yonghui;ZHU, Yan;ZHOU, Juan;GAO, Yujun;WANG, Shiqun;WANG, Dong;LIU, Wandeng;SHEN, Ximing;HONG, Binbin;LIU, Tao;WU, Yaodong;LI, Chunqi US2018/271846, 2018, A1 Location in patent:Paragraph 0176; 0180; 0181
10250-62-1
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10250-64-3
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98-86-2
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10250-64-3
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89088-56-2
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10250-64-3
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6296-54-4
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$21.75/1g
10250-64-3
80 suppliers
$21.00/100mg