1-(PROPANE-2-SULFONYL)-PIPERAZINE synthesis
- Product Name:1-(PROPANE-2-SULFONYL)-PIPERAZINE
- CAS Number:534615-34-4
- Molecular formula:C7H16N2O2S
- Molecular Weight:192.28
Yield:534615-34-4 84%
Reaction Conditions:
with triethylamine in dichloromethane at 0 - 20; for 16 h;
Steps:
4.C
8: To a solution of piperazine (1 g) and triethylamine (1.78 mL) in dichloromethane (20 mL) at 0° C. was added dropwise 2-propanesulfonyl chloride (1.30 mL). The reaction mixture was stirred at room temperature for 16 h and then quenched with water (20 mL) and extracted into dichloromethane (2*40 mL). The combined organic layers were washed with saturated aqueous brine solution (2*40 mL), dried (MgSO4) and concentrated to afford 1-(propane-2-sulfonyl)-piperazine as a white solid (1.87 g, 84%).
References:
US2008/76758,2008,A1 Location in patent:Page/Page column 88
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