1-Propanesulfonamide, N-(3-bromo-2-fluorophenyl)- synthesis
- Product Name:1-Propanesulfonamide, N-(3-bromo-2-fluorophenyl)-
- CAS Number:1269233-04-6
- Molecular formula:C9H11BrFNO2S
- Molecular Weight:296.16
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Yield:1269233-04-6 60%
Reaction Conditions:
with pyridine at 60; for 3 h;Inert atmosphere;
Steps:
N-(3-bromo-2-fluorophenyl)propane-1-sulfonamide
To a solution of 3-bromo-2-fluoroaniline (1.0 g, 5.26 mmol) in pyridine (10 mL) was added propane-1-sulfonyl chloride (5.92 mL, 52.62 mmol) and the reaction mixture was stirred at 60° C. for 3 hours under argon atmosphere.
The reaction mixture was cooled to ambient temperature and the solvent was removed under reduced pressure.
The crude product was purified by silica gel column chromatography (5% ethyl acetate in hexane) to provide N-(3-bromo-2-fluorophenyl)propane-1-sulfonamide as a pale yellow solid (950 mg, 60%).
1H NMR (400 MHz, DMSO-d6) δ 9.86 (s, 1H), 7.57-7.48 (m, 1H), 7.46-7.37 (m, 1H), 7.19-7.10 (m, 1H), 3.16-3.08 (m, 2H), 1.80-1.66 (m, 2H), 0.97 (t, J=7.4 Hz, 3H).
References:
US2020/407344,2020,A1 Location in patent:Paragraph 0945; 0946
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