10-Oxo-10,11-Dihydro-5H-dibenz[b,f]azepine synthesis
- Product Name:10-Oxo-10,11-Dihydro-5H-dibenz[b,f]azepine
- CAS Number:21737-58-6
- Molecular formula:C14H11NO
- Molecular Weight:209.24
4698-11-7
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21737-58-6
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$58.00/250mg
Yield:21737-58-6 97%
Reaction Conditions:
with hydrogenchloride;water in acetone at 20; for 1 - 1.5 h;
Steps:
1
EXAMPLE I; Preparation of 5,11-Dihydro-10H-dibenz[b,f]azepine-10-one (Oximinostilbene) IV; A 2-L, three-necked flask equipped with a mechanical stirrer, thermometer and nitrogen inlet was charged with 10-methoxyiminostilbene I (110.0 g, 0.49 mol) and 330 mL acetone. A 10% solution of hydrochloric acid (28.6 g, 0.08 mol) was then added. The reaction mixture was stirred at ambient temperature for 1-1.5 hours until reaction completion. The product was precipitated by the addition of 660 mL of deionized water, and the resulting suspension was stirred for 3-4 hours. The suspension was filtered and washed with water. After drying, oximinostilbene (99.92 g, 97%) was obtained as a bright yellow solid having a purity of 99% by HPLC. 1H NMR (CDCl3, d): 3.80, 6.87, 7.04-7.15, 7.22-7.24, 7.32-7.37, 8.04 ppm.
References:
Apotex Pharmachem Inc. US2005/282797, 2005, A1 Location in patent:Page/Page column 3
![5-Acetyl-5H-dibenzo[b,f]azepin-10(11H)-one](/CAS/GIF/28291-63-6.gif)
28291-63-6
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21737-58-6
129 suppliers
$58.00/250mg
869668-73-5
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21737-58-6
129 suppliers
$58.00/250mg
![10,11-Dihydro-10-oxo-5H-dibenzo[b,f]azepine-5-carboxylicacidMethylester](/CAS/20180808/GIF/353497-31-1.gif)
353497-31-1
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21737-58-6
129 suppliers
$58.00/250mg
4698-11-7
267 suppliers
$5.00/1g
7440-44-0
318 suppliers
$12.00/25g
21737-58-6
129 suppliers
$58.00/250mg