ethyl (2E)-3-(4-chloro-3-nitrophenyl)-2-cyanoprop-2-enoate synthesis

Yield:100124-55-8 96%

Reaction Conditions:

with N-(propylcarbamoyl)sulfamic acid bonded on silica at 100; for 0.25 h;

Steps:

2.3. General procedure for the synthesis of substituted benzylidene acrylate 3(a-p)

General procedure: A mixture of aldehyde 1(a-p) (1.59 mmol), ethyl cyanoacetate(1.59 mmol) and silica bonded N-(propylcarbamoyl)sulfamic acid(SBPCSA) 200 mg was heated at 100 °C with stirring for the specified time (Table 8). After completion of the reaction (monitored by TLC),the catalyst was flltered of washed with ethyl acetate, dried in the and reused. The organic layer was evaporated under reduced pressureto get the products 3(a-p). The recrystallization of products 3(a-p) was done using a mixture of methanol and chloroform (10:1). Scheme 1.

References:

Aslam, Afroz;Parveen, Mehtab;Alam, Mahboob;Silva, Manuela Ramos;Silva, P.S. Pereira [Biophysical Chemistry,2020,vol. 266,art. no. 106443]