3-AZETIDINECARBOXYLIC ACID, METHYL ESTER, HYDROCHLORIDE synthesis
- Product Name:3-AZETIDINECARBOXYLIC ACID, METHYL ESTER, HYDROCHLORIDE
- CAS Number:100202-39-9
- Molecular formula:C5H10ClNO2
- Molecular Weight:151.59
53871-06-0
100202-39-9
The general procedure for the synthesis of methyl azetidine-3-carboxylate hydrochloride from methyl 1 -diphenylmethylazetidine-3-carboxylate was as follows (Preparative Example 85): methyl 1 -diphenylmethylazetidine-3-carboxylate (3.57 g) was dissolved in methanol (360 ml), and ethyl acetate solution of 4N hydrochloric acid (12.7 ml) was added, and the reaction system was maintained at 20 °C. Subsequently, palladium hydroxide (3.57 g) was added as a catalyst and the reaction was stirred at room temperature and under pressurized hydrogen atmosphere (0.4 MPa) for 11 hours. After completion of the reaction, the catalyst was removed by filtration and washed with methanol and water. The filtrate was concentrated to give the crude product of methyl azetidine-3-carboxylate hydrochloride, which presented as a light yellow oil. The reaction was assessed to be quantitative and 1.93 g of product was obtained, which can be used directly in subsequent reactions. The product was detected by ESI-MS, m/z: 116 [M + H]+.
67-56-1
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36476-78-5
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100202-39-9
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Yield:100202-39-9 100%
Reaction Conditions:
with thionyl chloride in acetonitrile at 0 - 20; for 2.33333 h;
Steps:
34.B
To a stirring suspension of 3-azetidine carboxylic acid in MeOH at O0C3 was added SOCl2 dropwise. After 20 minutes, the ice bath was removed, the solution was warmed to rt and was stirred for 2 hours. The solvent was removed in vaccuo to afford the title compound as its HCl salt (1.5g, 100%). 1H NMR (400 MHz, CD3OD) δ 3.71 - 3.77 (m, 1 H) 3.77 (s, 3 H) 4.18 - 4.31 (m, 4 H).
References:
AstraZeneca AB WO2006/33633, 2006, A1 Location in patent:Page/Page column 68
53871-06-0
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100202-39-9
202 suppliers
$7.00/1g
36476-78-5
436 suppliers
$6.00/1g
100202-39-9
202 suppliers
$7.00/1g