3-AZETIDINECARBOXYLIC ACID, METHYL ESTER, HYDROCHLORIDE synthesis
- Product Name:3-AZETIDINECARBOXYLIC ACID, METHYL ESTER, HYDROCHLORIDE
- CAS Number:100202-39-9
- Molecular formula:C5H10ClNO2
- Molecular Weight:151.59
67-56-1
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36476-78-5
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$6.00/1g
100202-39-9
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Yield:100202-39-9 100%
Reaction Conditions:
with thionyl chloride in acetonitrile at 0 - 20; for 2.33333 h;
Steps:
34.B
To a stirring suspension of 3-azetidine carboxylic acid in MeOH at O0C3 was added SOCl2 dropwise. After 20 minutes, the ice bath was removed, the solution was warmed to rt and was stirred for 2 hours. The solvent was removed in vaccuo to afford the title compound as its HCl salt (1.5g, 100%). 1H NMR (400 MHz, CD3OD) δ 3.71 - 3.77 (m, 1 H) 3.77 (s, 3 H) 4.18 - 4.31 (m, 4 H).
References:
AstraZeneca AB WO2006/33633, 2006, A1 Location in patent:Page/Page column 68
53871-06-0
93 suppliers
$38.00/1 g
100202-39-9
182 suppliers
$7.00/1g
36476-78-5
411 suppliers
$6.00/1g
100202-39-9
182 suppliers
$7.00/1g