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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
1003316-11-7

N-[3-[[4-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]benzoyl]amino][1,1'-biphenyl]-4-yl]carbamic Acid tert-Butyl Ester synthesis

8synthesis methods
N-[3-[[4-(ChloroMethyl)benzoyl]aMino][1,1'-biphenyl]-4-yl]carbaMic Acid tert-Butyl Ester

1003316-10-6
8 suppliers
$675.00/50mg

Potassium phthalimide

1074-82-4
502 suppliers
$5.00/25g

N-[3-[[4-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]benzoyl]amino][1,1'-biphenyl]-4-yl]carbamic Acid tert-Butyl Ester

1003316-11-7
9 suppliers
$625.00/25mg

-

Yield:-

Reaction Conditions:

with potassium iodide in N,N-dimethyl-formamide at 50;

Steps:



1 , 1 -dimethyl ethyl [3-( { [4-(chloromethyl)phenyl] carbonyl}amino)biphenyl-4-yl]carbamate (20 g, 45.8 mmol), potassium phthalimide (9.33 g, 50.4 mmol) and potassium iodide (1.52 g, 9.15 mmol) were stirred in DMF (81 mL) at 50 0C overnight. Room temperature was attained, H2O was added and the products extracted into EtOAc (x2). The combined organic extracts were washed with brine, dried over MgSO4 and concentrated in vacuo. The residue was triturated in MeOH to give 1,1-dimethylethyl {3-[({4- [( 1 ,3-dioxo- 1 ,3-dihydro-2H-isoindol-2-yl)methyl]phenyl} carbonyl)amino]biphenyl-4- yl} carbamate as a pale yellow solid.

References:

WO2008/10985,2008,A2 Location in patent:Page/Page column 166-167

335255-33-9 Synthesis
N-(3-AMino[1,1'-biphenyl]-4-yl)-carbaMic Acid tert-Butyl Ester

335255-33-9
20 suppliers
$640.00/50mg

N-[3-[[4-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]benzoyl]amino][1,1'-biphenyl]-4-yl]carbamic Acid tert-Butyl Ester

1003316-11-7
9 suppliers
$625.00/25mg

References
Phthalimide

85-41-6
490 suppliers
$9.00/1g

N-[3-[[4-(ChloroMethyl)benzoyl]aMino][1,1'-biphenyl]-4-yl]carbaMic Acid tert-Butyl Ester

1003316-10-6
8 suppliers
$675.00/50mg

N-[3-[[4-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]benzoyl]amino][1,1'-biphenyl]-4-yl]carbamic Acid tert-Butyl Ester

1003316-11-7
9 suppliers
$625.00/25mg

References
4-(Chloromethyl)benzoyl chloride

876-08-4
275 suppliers
$11.00/25g

N-[3-[[4-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]benzoyl]amino][1,1'-biphenyl]-4-yl]carbamic Acid tert-Butyl Ester

1003316-11-7
9 suppliers
$625.00/25mg

References
875-51-4 Synthesis
4-Bromo-2-nitroaniline

875-51-4
307 suppliers
$5.00/1g

N-[3-[[4-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]benzoyl]amino][1,1'-biphenyl]-4-yl]carbamic Acid tert-Butyl Ester

1003316-11-7
9 suppliers
$625.00/25mg

References