ChemicalBook CAS DataBase List (3S,4S)-tert-Butyl 3-amino-4-fluoropyrrolidine-1-carboxylate

(3S,4S)-tert-Butyl 3-amino-4-fluoropyrrolidine-1-carboxylate synthesis

2synthesis methods

Product Name:(3S,4S)-tert-Butyl 3-amino-4-fluoropyrrolidine-1-carboxylate
CAS Number:1009075-43-7
Molecular formula:C9H17FN2O2
Molecular Weight:204.24

252574-03-1 Synthesis

(3S,4S)-N-Boc-3-(benzylamino)-4-hydroxypyrrolidine

252574-03-1
49 suppliers
$129.00/2mg

(3S,4S)-tert-Butyl 3-amino-4-fluoropyrrolidine-1-carboxylate

1009075-43-7
71 suppliers
$225.00/100MG

Yield:-

Steps:

Multi-step reaction with 4 steps
1.1: 1H-imidazole; thionyl chloride; triethylamine / dichloromethane / 1 - 20 °C
2.1: rhodium(III) chloride hydrate; sodium periodate / acetonitrile; water; 1,2-dichloro-ethane / 18 h / 2 - 18 °C
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / Reflux
3.2: 2 h
4.1: hydrogen; palladium 10% on activated carbon / ethanol

References:

CARLSON, ERIC;HANSEN, HANS;HAWKINS, LYNN;ISHIZAKA, SALLY;MACKEY, MATTHEW;SCHILLER, SHAWN;OGAWA, CHIKAKO;DAVIS, HEATHER US2015/105370, 2015, A1

tert-butyl(3S,4S)-3-azido-4-fluoropyrrolidine-1-carboxylate

913743-06-3
1 suppliers
inquiry

1009075-43-7
71 suppliers
$225.00/100MG

References