(3S,4S)-tert-Butyl 3-amino-4-fluoropyrrolidine-1-carboxylate synthesis
- Product Name:(3S,4S)-tert-Butyl 3-amino-4-fluoropyrrolidine-1-carboxylate
- CAS Number:1009075-43-7
- Molecular formula:C9H17FN2O2
- Molecular Weight:204.24
252574-03-1
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$129.00/2mg
1009075-43-7
67 suppliers
$225.00/100MG
Yield:-
Steps:
Multi-step reaction with 4 steps
1.1: 1H-imidazole; thionyl chloride; triethylamine / dichloromethane / 1 - 20 °C
2.1: rhodium(III) chloride hydrate; sodium periodate / acetonitrile; water; 1,2-dichloro-ethane / 18 h / 2 - 18 °C
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / Reflux
3.2: 2 h
4.1: hydrogen; palladium 10% on activated carbon / ethanol
References:
CARLSON, ERIC;HANSEN, HANS;HAWKINS, LYNN;ISHIZAKA, SALLY;MACKEY, MATTHEW;SCHILLER, SHAWN;OGAWA, CHIKAKO;DAVIS, HEATHER US2015/105370, 2015, A1
913743-06-3
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inquiry
1009075-43-7
67 suppliers
$225.00/100MG