(3S,4S)-N-Boc-3-(benzylamino)-4-hydroxypyrrolidine synthesis
- Product Name:(3S,4S)-N-Boc-3-(benzylamino)-4-hydroxypyrrolidine
- CAS Number:252574-03-1
- Molecular formula:C16H24N2O3
- Molecular Weight:292.37
![1-Pyrrolidinecarboxylic acid, 3-hydroxy-4-[(phenylmethyl)amino]-, 1,1-dimethylethyl ester, (3S,4S)-, mono[(αS)-α-hydroxybenzeneacetate] (salt) (9CI)](/CAS/20211123/GIF/252574-04-2.gif)
252574-04-2
0 suppliers
inquiry
252574-03-1
50 suppliers
$129.00/2mg
Yield:252574-03-1 65%
Reaction Conditions:
with water;potassium carbonate
Steps:
57
PREPARATION 57 (3S,4S)-3-Benzylamino-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester To (3S,4S)-3-benzylamino-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester (+)-mandelic acid salt (60.0 g) add 3% aqueous potassium carbonate (300 mL) and extract the free amine with ethyl acetate (3*250 mL). Wash the combined organic layer with brine and dry over anhydrous sodium sulfate. Evaporate the solvent under reduced pressure to obtain the (S,S)-enantiomer as a white solid (34.0 g, 65%). APCI MS m/z 293 [M+H]+; mp 69-70° C., [α]23D+18.0° (c, 0.50, MeOH).
References:
US2009/163472,2009,A1 Location in patent:Page/Page column 25
24424-99-5
869 suppliers
$13.50/25G
252574-03-1
50 suppliers
$129.00/2mg
73286-70-1
289 suppliers
$6.00/5g
252574-03-1
50 suppliers
$129.00/2mg
![3-Boc-6-oxa-3-aza-bicyclo[3.1.0]hexane](/CAS/GIF/114214-49-2.gif)
114214-49-2
172 suppliers
$9.00/1g
252574-03-1
50 suppliers
$129.00/2mg
4248-19-5
380 suppliers
$5.00/5g
252574-03-1
50 suppliers
$129.00/2mg