ethyl 2-[(1-oxo-1,2-dihydroisoquinolin-5-yl)oxy]propanoate synthesis
1synthesis methods
- Product Name:ethyl 2-[(1-oxo-1,2-dihydroisoquinolin-5-yl)oxy]propanoate
- CAS Number:1014107-39-1
- Molecular formula:C14H15NO4
- Molecular Weight:261.27
Yield:1014107-39-1 80%
Reaction Conditions:
Stage #1: 1,5-dihydroxy-1(2H)-isoquinolinewith sodium hydride in N,N-dimethyl-formamide at 25; for 0.5 h;
Stage #2: Ethyl 2-bromopropionateFurther stages.;
References:
Roth, Joshua;Madoux, Franck;Hodder, Peter;Roush, William R. [Bioorganic and Medicinal Chemistry Letters,2008,vol. 18,# 8,p. 2628 - 2632]