1-Phenyl-6-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione synthesis
- Product Name:1-Phenyl-6-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
- CAS Number:1015-64-1
- Molecular formula:C11H10N2O2
- Molecular Weight:202.21
Yield:1015-64-1 40.7%
Reaction Conditions:
in N,N-dimethyl-formamide;Reflux;
Steps:
19-2 6-methyl-1-phenylpyrimidine-2,4(1H,3H)-dione
To a solution of 19b (20 g, 106 mmol) in DMF (15 mL) was added aniline (9.2 mL) at r.t., the reaction was stirred at reflux until 20b disappeared by TLC. The mixture was concentrated, the residue was washed with EtOH, and filtered to give 19c as a yellow solid (880 mg, yield: 40.7%). MS (m/z): 203.1 (M+1)+.
References:
WO2014/15523,2014,A1 Location in patent:Page/Page column 103; 104
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