(1R,2R,3R,5R)-(2-TERT-BUTOXYCARBONYLAMINO)-6,6-DIMETHYLBICYCLO[3.1.1]HEPTAN-3-CARBOXYLIC ACID synthesis
- Product Name:(1R,2R,3R,5R)-(2-TERT-BUTOXYCARBONYLAMINO)-6,6-DIMETHYLBICYCLO[3.1.1]HEPTAN-3-CARBOXYLIC ACID
- CAS Number:1027343-75-4
- Molecular formula:C15H25NO4
- Molecular Weight:283.36
![(1R,2R,3R,5R)-2-Amino-6,6-dimethylbicyclo[3.1.1]heptan-3-carboxylic acid hydrochloride](/CAS2/GIF/1027343-52-7.gif)
1027343-52-7
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1027343-75-4
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Yield:1027343-75-4 65%
Reaction Conditions:
Stage #1: (1R,2R,5R,7R)-2-amino-6,6-dimethylbicyclo[3.3.1]heptane-3-carboxylic acid hydrochloridewith sodium hydroxide in water at 0; pH=8;
Stage #2: di-tert-butyl dicarbonatewith sodium hydroxide in 1,4-dioxane;water at 20; pH=8; for 6 h;
Stage #3: with hydrogenchloride in 1,4-dioxane;water; pH=5;
References:
Szakonyi, Zsolt;Martinek, Tamas A.;Sillanpaeae, Reijo;Fueloep, Ferenc [Tetrahedron Asymmetry,2008,vol. 19,# 19,p. 2296 - 2303] Location in patent:experimental part