2-PHENYL-IMIDAZO[1,2-A]PYRIDINE-7-CARBOXYLIC ACID METHYL ESTER synthesis
- Product Name:2-PHENYL-IMIDAZO[1,2-A]PYRIDINE-7-CARBOXYLIC ACID METHYL ESTER
- CAS Number:1030-33-7
- Molecular formula:C15H12N2O2
- Molecular Weight:252.27
Yield:1030-33-7 85%
Reaction Conditions:
with sodium hydrogencarbonate in methanol; for 3 h;Reflux;Inert atmosphere;
Steps:
1.1
Example 1; 4-Chloro-2-methyl-2H-pyrazole-3-carboxylic acid (2-phenyl-imidazo[1,2-a]pyridin-7-yl)-amide Step 1: 2-Phenyl-imidazo[1,2-a]pyridine-7-carboxylic acid methyl esterA mixture of 2-amino-isonicotinic acid methyl ester (5 g, 32 mmol), ω-bromoacetophenone (6.47 g, 32 mmol), NaHCO3 (2.95 g, 35 mmol) and methanol (30 ml) was heated under an atmosphere of argon to reflux (3 h). After cooling, water (20 ml) was added, the mixture was stirred at r.t. (15 min), and filtered. The obtained solid was washed (water, methanol, diethyl ether) and dried under vacuum. The product (6.8 g, 85%) was used in the next step without further purification. MS (m/e)=253.2 [M+H+].
References:
US2011/71128,2011,A1 Location in patent:Page/Page column 12-13
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