1-(2-FLUOROETHYL)-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1 H-PYRAZOLE synthesis
- Product Name:1-(2-FLUOROETHYL)-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1 H-PYRAZOLE
- CAS Number:1049730-39-3
- Molecular formula:C11H18BFN2O2
- Molecular Weight:240.08
269410-08-4
404 suppliers
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762-51-6
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$6.00/1g
1049730-39-3
46 suppliers
$155.00/50mg
Yield:1049730-39-3 504 mg
Reaction Conditions:
Stage #1: pyrazole-4-boronic acid pinacol esterwith sodium hydride in N,N-dimethyl-formamide;mineral oil at 0 - 20; for 0.333333 h;Inert atmosphere;
Stage #2: 1-fluoro-2-iodoethane in N,N-dimethyl-formamide;mineral oil at 20; for 4 h;Inert atmosphere;
References:
Katz, Jason D.;Jewell, James P.;Guerin, David J.;Lim, Jongwon;Dinsmore, Christopher J.;Deshmukh, Sujal V.;Pan, Bo-Sheng;Marshall, C. Gary;Lu, Wei;Altman, Michael D.;Dahlberg, William K.;Davis, Lenora;Falcone, Danielle;Gabarda, Ana E.;Hang, Gaozhen;Hatch, Harold;Holmes, Rachael;Kunii, Kaiko;Lumb, Kevin J.;Lutterbach, Bart;Mathvink, Robert;Nazef, Naim;Patel, Sangita B.;Qu, Xianlu;Reilly, John F.;Rickert, Keith W.;Rosenstein, Craig;Soisson, Stephen M.;Spencer, Kerrie B.;Szewczak, Alexander A.;Walker, Deborah;Wang, Wenxian;Young, Jonathan;Zeng, Qinwen [Journal of Medicinal Chemistry,2011,vol. 54,# 12,p. 4092 - 4108] Location in patent:supporting information; experimental part
269410-08-4
404 suppliers
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762-49-2
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1049730-39-3
46 suppliers
$155.00/50mg