tert-butyl ((3S,4S)-1-benzyl-4-fluoropiperidin-3-yl)carbamate synthesis
- Product Name:tert-butyl ((3S,4S)-1-benzyl-4-fluoropiperidin-3-yl)carbamate
- CAS Number:1052713-39-9
- Molecular formula:C18H25FN2O4
- Molecular Weight:352.4
13139-17-8
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![tert-butyl N-[(3S,4S)-4-fluoropiperidin-3-yl]carbamate](/CAS/GIF/1052713-48-0.gif)
1052713-48-0
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Yield:-
Reaction Conditions:
with triethylamine in tetrahydrofuran at 20; for 24 h;
Steps:
4.1 Step 1.
Triethylamine (0.19 mL, 1.37 mmol) was added to a solution of tert-butyl N-[(3S,4S)-4- fluoro-3-piperidyl]carbamate (250 mg, 1.15 mmol) in tetrahydrofuran (3 mL), followed by addition of N-(Benzyloxycabronyloxy) succinimide (430 mg, 1.73 mmol). The resulting reaction mixture was stirred at room temperature for 24 h. The reaction mixture was diluted with ethyl acetate and quenched with saturated ammonium chloride solution, extracting with ethyl acetate twice. The combined organics were dried over magnesium sulfate and concentrated to produce the crude product, which was purified via silica gel column chromatography (0-40% ethyl acetate in hexanes) to yield benzyl (3S,4S)-3-(tert-butoxycarbonylamino)-4-fluoro-piperidine-1- carboxylate. ES/MS: m/z 353.74 [M+H]+.
References:
WO2021/222353,2021,A1 Location in patent:Page/Page column 377; 396
![1-Piperidinecarboxylic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-fluoro-, phenylmethyl ester](/CAS/20210305/GIF/1214242-81-5.gif)
24424-99-5
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1052713-38-8
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1052713-39-9
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66207-08-7
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1052713-38-8
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1052713-39-9
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