6-AMINO-2,2-DIMETHYL-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE synthesis

Yield:-

Reaction Conditions:

with hydrogen;palladium 10% on activated carbon in tetrahydrofuran;methanol at 20;

Steps:

1.6 Synthesis of 6-amino-2,2-dimethyl-4H-benzo[1,4]oxazin-3-one

Synthesis of 6-amino-2,2-dimethyl-4H-benzo[1,4]oxazin-3-one 10%Pd-C (100 mg) was added to tetrahydrofuran:methanol=1:1 (50 mL) solution of the compound (500.0 mg) prepared in of Example 1 was stirred under hydrogen atmosphere at room temperature overnight. The reaction mixture was subjected to Celite filtration. The solvent was then distilled off under reduced pressure. n-Hexane and diethyl ether were added to the residue to solidify the resulting product. The title compound (380.0 mg) was obtained as a pale brown solid.

References:

EP2128157,2009,A1 Location in patent:Page/Page column 98