8-FLUORO-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE synthesis
- Product Name:8-FLUORO-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE
- CAS Number:560082-51-1
- Molecular formula:C8H6FNO2
- Molecular Weight:167.14
698984-51-9
0 suppliers
inquiry
560082-51-1
20 suppliers
inquiry
Yield:560082-51-1 82%
Reaction Conditions:
Stage #1: (2-fluoro-6-nitrophenoxy)acetic acid, methyl esterwith iron;acetic acid at 20;
Stage #2: with sodium hydrogencarbonate;sodium hydroxide pH=7;
Steps:
Intermediate 7: 8-Fluoro-4H-benzo[l,4]oxazin-3-oneA stirred mixture of (2-fluoro-6-nitrophenoxy)acetic acid, methyl ester (1.44g, 0.0073mol) and iron powder (2.44g, 0.0438mol) in acetic acid (50mL) was stirred at room temperature overnight. The pH of the reaction mixture was adjusted to 7 by using sodium bicarbonate and sodium hydroxide solutions. The mixture was diluted with ethyl acetate. Water was added and the mixture was extracted with dichloromethane. The organic phase was dried (MgS04) and the solvent removed under reduced pressure. The residue was triturated with diethyl ether to afford 8- fluoro-4H-benzo[ l,4]oxazin-3-one as a yellow solid (l .Og, 82%).NMR: 5H (^-DMSO) 4.63 (2H, s), 6.70 (1H, d), 6.88 (2H, m) and 10.88 (1H, br s).
References:
WO2011/144578,2011,A1 Location in patent:Page/Page column 29; 30
53981-25-2
119 suppliers
$25.30/250mg
79-04-9
374 suppliers
$12.00/5g
560082-51-1
20 suppliers
inquiry
1526-17-6
191 suppliers
$6.00/1g
560082-51-1
20 suppliers
inquiry