ethyl 7-bromo-3-(3-hydroxypropyl)-1H-indole-2-carboxylate synthesis
- Product Name:ethyl 7-bromo-3-(3-hydroxypropyl)-1H-indole-2-carboxylate
- CAS Number:1073067-97-6
- Molecular formula:C14H16BrNO3
- Molecular Weight:326.19
615-36-1
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1073067-97-6
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Yield:-
Steps:
Multi-step reaction with 3 steps
1.1: hydrogenchloride; sodium nitrite / water / 0 °C
1.2: 2 h / 0 - 19 °C
1.3: Reflux
2.1: hydrogenchloride; acetic acid / 3 h / 80 °C
3.1: borane-THF / tetrahydrofuran / 16 h / -15 °C / Inert atmosphere
References:
Bruncko, Milan;Wang, Le;Sheppard, George S.;Phillips, Darren C.;Tahir, Stephen K.;Xue, John;Erickson, Scott;Fidanze, Steve;Fry, Elizabeth;Hasvold, Lisa;Jenkins, Gary J.;Jin, Sha;Judge, Russell A.;Kovar, Peter J.;Madar, David;Nimmer, Paul;Park, Chang;Petros, Andrew M.;Rosenberg, Saul H.;Smith, Morey L.;Song, Xiaohong;Sun, Chaohong;Tao, Zhi-Fu;Wang, Xilu;Xiao, Yu;Zhang, Haichao;Tse, Chris;Leverson, Joel D.;Elmore, Steven W.;Souers, Andrew J. [Journal of Medicinal Chemistry,2015,vol. 58,# 5,p. 2180 - 2194]
1073493-75-0
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1073067-97-6
22 suppliers
$111.00/100mg
1073067-96-5
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1073067-97-6
22 suppliers
$111.00/100mg
611-10-9
408 suppliers
$10.00/5g
1073067-97-6
22 suppliers
$111.00/100mg