5-aMino-1-(4,4-difluorocyclohexyl)-1H-pyrazole-4-carboxaMide synthesis
- Product Name:5-aMino-1-(4,4-difluorocyclohexyl)-1H-pyrazole-4-carboxaMide
- CAS Number:1082745-54-7
- Molecular formula:C10H14F2N4O
- Molecular Weight:244.24
1082745-53-6
10 suppliers
inquiry
1082745-54-7
5 suppliers
inquiry
Yield:1082745-54-7 68%
Reaction Conditions:
with ammonia;dihydrogen peroxide in ethanol;water at 20; for 2.16667 h;
Steps:
4A
Example 4A; 3.88 g (14.6 mmol) of Example 3A were mixed with 40 ml_ of ethanol. At room temperature a solution of 35 ml_ (0.41 mol) hydrogen peroxide (35 % in water) in 20 ml_ ammonia (25 % in water) was added over a period of 10 min. The reaction mixture was stirred at room temperature for 2h. The solution was concentrated to a volume of 50 ml_ under reduced pressure. The residue was mixed withdichloromethane and water. The organic layer was extracted with water and 40 % Na2S2θ3 solution. The organic layer was dried, filtered and the filtrate was concentrated under reduced pressure. 2.44 g (68 %) of the product were obtained. HPLC-MS (Method 1 ): R1 = 0.91 minMS (ESI pos): m/z = 245 (M+H)+
References:
WO2011/18495,2011,A1 Location in patent:Page/Page column 76
22515-18-0
246 suppliers
$5.00/100mg
1082745-54-7
5 suppliers
inquiry
1214910-72-1
9 suppliers
inquiry
1082745-54-7
5 suppliers
inquiry
1214910-81-2
1 suppliers
inquiry
1082745-54-7
5 suppliers
inquiry