ChemicalBook CAS DataBase List 4,4-DIFLUOROCYCLOHEXANONE

4,4-DIFLUOROCYCLOHEXANONE synthesis

5synthesis methods

Product Name:4,4-DIFLUOROCYCLOHEXANONE
CAS Number:22515-18-0
Molecular formula:C6H8F2O
Molecular Weight:134.12

176251-49-3
49 suppliers
$8.00/250mg

22515-18-0
231 suppliers
$5.00/100mg

Yield:22515-18-0 93%

Reaction Conditions:

with hydrogenchloride;water at 100; for 12 h;

Steps:

84.2 Step 2. 4, 4-Difluorocyclohexanone (84c)
Compound 84b (1 g, 5.6 mmol) was dissolved in aq. HCl (2 mL, 2N) . The resulting mixture was stirred at 100 for 12 hrs. After cooling down to RT, the mixture was diluted with DCM (10 mL) and adjusted to pH = 78 with sat. NaHCO 3. The separated organic layer was washed with sat. NaHCO 3, dried over Na 2SO 4 and filtered. The filtrate was concentrated to dryness to afford the desired product as colorless oil (700 mg, 93%yield) . 1H NMR (400 MHz, CDCl 3) δ 2.56 -2.53 (m, 4H) , 2.36 -2.27 (m, 4H) . 19F NMR (376 MHz, CDCl 3) δ -100.27.

References:

LYNK PHARMACEUTICALS CO. LTD.;WAN, Zhaokui;VAZQUEZ, Michael Lawrence;LI, Xiaodong WO2020/119819, 2020, A1 Location in patent:Paragraph 00395

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4746-97-8 Synthesis