1-(2-Cyano-phenyl)-cyclopropanecarboxylic acid Methyl ester synthesis
- Product Name:1-(2-Cyano-phenyl)-cyclopropanecarboxylic acid Methyl ester
- CAS Number:1092794-06-3
- Molecular formula:C12H11NO2
- Molecular Weight:201.22
Yield:1092794-06-3 96%
Reaction Conditions:
with tetrabutylammomium bromide;sodium hydroxide in water;toluene at 15 - 30; for 1 h;
Steps:
14.2 step 2
1,2-dibromoethane (8.05 g, 42 mmol), Compound 10.2 (5.0 g, 28 mmol), Tetrabutylammonium bromide (catalytic amount), A mixed solution of aqueous sodium hydroxide solution (50%, 20 mL) and toluene (40 mL) was stirred at room temperature for 1 hour. The reaction system is diluted with water, Extracted with ethyl acetate, The organic phases were combined and washed with brine. The organic phase is dried over anhydrous sodium sulfate. filter, concentrate, The residue was chromatographed on silica gel (20% ethyl acetate petroleum ether) Purification afforded compound 10.3 (5.5 g, yield: 96%) It is a colorless oil.
References:
CN108623615,2018,A Location in patent:Paragraph 0332; 0414; 0415; 0417
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