2-(4-bromo-3-fluorophenyl)-5-methyl-1,3,4-oxadiazole synthesis
- Product Name:2-(4-bromo-3-fluorophenyl)-5-methyl-1,3,4-oxadiazole
- CAS Number:1093064-67-5
- Molecular formula:C9H6BrFN2O
- Molecular Weight:257.06
1093064-27-7
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Yield:1093064-67-5 32%
Reaction Conditions:
at 100; for 18 h;
Steps:
84.1
A mixture of Compound 2BF (0.9 g, 2.53 mmol) and triethylacetate (5 mL) was heated at 100 °C for 18 hours. Cooled to room temperature and poured into water (100 mL). Extracted with EtOAc (100 mL). The organic layer was dried (Na2SO4), filtered and concentrated. The residue was purified on silica gel eluting with 20% EtOAc/ hexane to give the desired product 17BF (0.36 g, 32%).
References:
WO2008/153858,2008,A1 Location in patent:Page/Page column 304
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153556-42-4
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