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(1R,3S)-3-(methoxycarbonyl)cyclopentane-1-carboxylic acid synthesis

9synthesis methods
-

Yield:1098881-13-0 96%

Reaction Conditions:

with 1-((1R,2R)-2-(dimethylamino)cyclohexyl)-3-phenylthiourea in diethyl ether at 20; for 24 h;Inert atmosphere;optical yield given as %ee;enantioselective reaction;

References:

Schmitt, Ellen;Schiffers, Ingo;Bolm, Carsten [Tetrahedron,2010,vol. 66,# 33,p. 6349 - 6357] Location in patent:experimental part