1-(6-Amino-5-methoxyindolin-1-yl)-2-(dimethylamino)ethanone synthesis
- Product Name:1-(6-Amino-5-methoxyindolin-1-yl)-2-(dimethylamino)ethanone
- CAS Number:1116229-84-5
- Molecular formula:C13H19N3O2
- Molecular Weight:249.31
1116229-90-3
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1116229-84-5
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Yield:1116229-84-5 56%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in methanol;ethyl acetate at 20; under 2585.81 Torr; for 4 h;
Steps:
55.4 1-(6-Amino-5-methoxy-indoline-1-yl)-2-(dimethylamino)ethanone
2-(Dimethylamino)-1-(5-methoxy-6-nitro-indoline-1-yl)acetyl (5.00 g, 17.90 mmol) was dissolved in ethyl acetate (100 mL) and In methanol (15 mL), wet palladium on carbon (10%, 600 mg) was added to the reaction solution. The reaction solution was reacted under a hydrogen (50 psi) atmosphere at 20°C for 4 hours. The reaction solution was filtered, and the filtrate was concentrated under reduced pressure to obtain a yellow solid, which was rinsed with a small amount of ethyl acetate to obtain 1-(6-amino-5-methoxy-indoline-1-yl)-2-(dimethylamino) Acetyl (2.50 g, pale yellow solid), yield: 56%.
References:
WO2022/199589,2022,A1 Location in patent:Page/Page column 47-48
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4770-33-6
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1116229-84-5
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$63.00/100mg