(2S)-2-(4-Bromo-phenyl)-morpholine-4-carboxylic acid tert-butyl ester synthesis
- Product Name:(2S)-2-(4-Bromo-phenyl)-morpholine-4-carboxylic acid tert-butyl ester
- CAS Number:1131220-37-5
- Molecular formula:C15H20BrNO3
- Molecular Weight:342.23
920798-90-9
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Yield:1131220-37-5 92%
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine in tetrahydrofuran at 20; for 17 h;
Steps:
208.b
b) (S)-tert-butyl 2-(4-bromophenyl)morpholine-4-carboxylate: (S)-2-(4-Bromo-phenyl)-morpholine (36.3 g, 150 mmol) and N,N-diisopropylethylamine (23.3 g, 31.4 ml, 180 mmol) in THF (360 ml) were treated with di-tert-butyl dicarbonate (39.3 g, 180 mmol). The reaction mixture was stirred for 17 h at rt, concentrated in vacuo, diluted with ethyl acetate, washed with 1 M-aq. citric acid (2 x 100 ml), dried over magnesium sulfate, filtered and concentrated in vacuo. The crude material was crystallized from hexane to afford 47.1 g (92%) (S)-tert-butyl 2-(4-bromophenyl)morpholine-4-carboxylate as an off-white solid. MS (ISP): 344.1 ([M+H]+).
References:
WO2011/76678,2011,A1 Location in patent:Page/Page column 124
1131220-34-2
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1131220-37-5
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83555-73-1
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1131220-37-5
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