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ChemicalBook CAS DataBase List ETHYL 4-(4-METHOXYPHENYL)-6-METHYL-2-THIOXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINECARBOXYLATE
113697-57-7

ETHYL 4-(4-METHOXYPHENYL)-6-METHYL-2-THIOXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINECARBOXYLATE synthesis

5synthesis methods
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Yield:113697-57-7 186 mg

Reaction Conditions:

Stage #1: 4-Methoxybenzyl alcoholwith Oxone;2,2,6,6-Tetramethyl-1-piperidinyloxy free radical;potassium bromide in neat (no solvent); for 0.5 h;Milling;Green chemistry;Biginelli Pyrimidone Synthesis;
Stage #2: ethyl acetoacetate;thiourea in neat (no solvent); for 3.5 h;Milling;Green chemistry;Biginelli Pyrimidone Synthesis;

References:

Sahoo, Prasit Kumar;Bose, Anima;Mal, Prasenjit [European Journal of Organic Chemistry,2015,vol. 2015,# 32,p. 6994 - 6998] Location in patent:supporting information