1-Amino-1-(hydroxymethyl)cyclopropane hydrochloride synthesis

Yield:-

Reaction Conditions:

with hydrogenchloride in 1,4-dioxane at 20;

Steps:

8.2 8.2 1-aminocyclopropanemethanol
8.2 1-aminocyclopropanemethanol 1.04 g tert-butyl (1-hydroxymethylcyclopropyl)-carbamidate are placed in 5 ml dioxane. 2.5 ml HCl in dioxane (4 mol/l) are added dropwise. The reaction mixture is stirred for 15 h at ambient temperature. The solvent is evaporated down by half and the precipitated solid is suction filtered. 0.5 g product are obtained as the hydrochloride. ¹H NMR (400 MHz, DMSO): 5.27 (1H, t); 0.91 (2H, t); 0.71 (2H, t).

References:

BOEHRINGER INGELHEIM INTERNATIONAL GMBH US2010/305102, 2010, A1 Location in patent:Page/Page column 16

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