ChemicalBook CAS DataBase List Methyl 8-oxo-5,6,7,8-tetrahydronaphthalene-2-carboxylate

Methyl 8-oxo-5,6,7,8-tetrahydronaphthalene-2-carboxylate synthesis

5synthesis methods

Product Name:Methyl 8-oxo-5,6,7,8-tetrahydronaphthalene-2-carboxylate
CAS Number:116047-26-8
Molecular formula:C12H12O3
Molecular Weight:204.22

67-56-1

8-OXO-5,6,7,8-TETRAHYDRO-NAPHTHALENE-2-CARBOXYLIC ACID

89781-52-2

116047-26-8

Intermediate VIII: Steps for the synthesis of methyl 8-oxo-5,6,7,8-tetrahydronaphthalene-2-carboxylate: Step a) Preparation of methyl 8-oxo-5,6,7,8-tetrahydronaphthalene-2-carboxylate: to a methanolic solution of 8-oxo-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid (16 g, 0.084 mol) was added sulfoxide chloride (23 g, 0.2 mol). The reaction mixture was stirred at room temperature for 12 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in ethyl acetate (200 mL), the organic layer was washed with 10% aqueous sodium bicarbonate, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give methyl 8-oxo-5,6,7,8-tetrahydronaphthalene-2-carboxylate 16 g (94% yield) as a liquid. Thin layer chromatography (TLC) conditions: chloroform/methanol (9/1, v/v), Rf = 0.9.

67-56-1 Synthesis

67-56-1
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201230-82-2 Synthesis

201230-82-2
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Methanesulfonic acid, 1,1,1-trifluoro-, 5,6,7,8-tetrahydro-8-oxo-2-naphthalenyl ester

144464-65-3
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116047-26-8
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$195.03/100mg

Yield:116047-26-8 95%

Reaction Conditions:

with 1,3-bis-(diphenylphosphino)propane;triethylamine;palladium diacetate in N,N-dimethyl-formamide;Carbonylation;

References:

Murphy, Paul V.;Hubbard, Rod E.;Manallack, David T.;Wills, Ruth E.;Montana, John G.;Taylor, Richard J. K. [Bioorganic and Medicinal Chemistry,1998,vol. 6,# 12,p. 2421 - 2439]

67-56-1 Synthesis

67-56-1
790 suppliers
$9.00/25ml

89781-52-2
50 suppliers
$213.00/1g

116047-26-8
40 suppliers
$195.03/100mg

References

67-56-1 Synthesis

67-56-1
790 suppliers
$9.00/25ml

201230-82-2 Synthesis

201230-82-2
1 suppliers
inquiry

32281-97-3 Synthesis