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ChemicalBook CAS DataBase List tert-butyl (3S,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate
1174020-40-6

tert-butyl (3S,4R)-3-fluoro-4-hydroxypiperidine-1-carboxylate synthesis

6synthesis methods
79099-07-3 Synthesis
N-(tert-Butoxycarbonyl)-4-piperidone

79099-07-3
0 suppliers
$5.00/5g

-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: sodium carbonate; N-fluorobis(benzenesulfon)imide; (R)-α-methylbenzylamine monotrichloroacetic acid / tetrahydrofuran / 24 h / -20 - -10 °C / Inert atmosphere
2: tetramethylammonium borohydride / methanol / 4.25 h / 0 °C / Inert atmosphere

References:

Shaw, Simon J.;Goff, Dane A.;Boralsky, Luke A.;Irving, Mark;Singh, Rajinder [Journal of Organic Chemistry,2013,vol. 78,# 17,p. 8892 - 8897]

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