tert-butyl (3S,4S)-3-fluoro-4-hydroxypiperidine-1-carboxylate synthesis

3synthesis methods

211108-50-8 Synthesis

Yield:-

Steps:

Multi-step reaction with 2 steps
1: methanol; sodium tetrahydroborate / 2 h
2: Chiralpak AD-H / methanol / Resolution of racemate

References:

PFIZER INC.;DAROUT, Etzer;GUIMARAES, Cristiano;MASCITTI, Vincent;MCCLURE, Kim F. WO2013/11402, 2013, A1

79099-07-3 Synthesis

211108-48-4 Synthesis

tert-butyl (3S,4S)-3-fluoro-4-hydroxypiperidine-1-carboxylate Related Search:

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