16-alpha,17-dihydroxy-alpha-methylbenzylidenedioxyprogesterone synthesis
1synthesis methods
- Product Name:16-alpha,17-dihydroxy-alpha-methylbenzylidenedioxyprogesterone
- CAS Number:1179-87-9
- Molecular formula:C29H36O4
- Molecular Weight:448.59
Yield:1179-87-9 78%
Reaction Conditions:
with perchloric acid at 20; for 10 h;Reagent/catalyst;Temperature;
Steps:
6
General procedure: The amount of perchloric acid of the hydroxyl group IV and 0.025 times the amount of the substance,10 times the amount of the material in the acetophenone reaction,The reaction temperature was 20 ° C,Reaction time is 10 hours,Get progesterone.The relative starting yield was 70%.Product purity of 98.9%.
References:
CN106866777,2017,A Location in patent:Paragraph 0026; 0033; 0038; 0043; 0048; 0053; 0054; 0055