METHYL 2-CYANO-2-(4-METHYLBENZYL)-3-P-TOLYLPROPANOATE synthesis
1synthesis methods
- Product Name:METHYL 2-CYANO-2-(4-METHYLBENZYL)-3-P-TOLYLPROPANOATE
- CAS Number:1202778-97-9
- Molecular formula:C20H21NO2
- Molecular Weight:307.39
Yield:1202778-97-9 100%
Reaction Conditions:
Stage #1: methyl 2-cyanoacetatewith sodium methylate in methanol at 20;
Stage #2: 4-Methylbenzyl bromide in methanol;Reflux;
References:
Hansen, Terkel;Alst, Tore;Havelkova, Martina;Str?m, Morten B. [Journal of Medicinal Chemistry,2010,vol. 53,# 2,p. 595 - 606] Location in patent:experimental part