5-N-Boc-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylic acid synthesis
- Product Name:5-N-Boc-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylic acid
- CAS Number:1209492-73-8
- Molecular formula:C12H17N3O4
- Molecular Weight:267.28
![Pyrazolo[1,5-a]pyrazine-2,5(4H)-dicarboxylic acid, 6,7-dihydro-, 5-(1,1-dimethylethyl) 2-methyl ester](/CAS/20200611/GIF/1209492-72-7.gif)
1209492-72-7
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1209492-73-8
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Yield:1209492-73-8 100%
Reaction Conditions:
with water;sodium hydroxide in tetrahydrofuran;methanol at 20; for 1.5 h;
Steps:
2-1.6
Step 6 To a solution of Compound 17 (2.10 g, 7.47 mmol) in tetrahydrofuran:methanol (1:1, 30 mL), aqueous 2 mol/L sodium hydroxide solution (7.47 mL, 14.9 mmol) was added. The solution was then stirred at room temperature for one and a half hours. Water was added to the reaction solution, acidified, and then extracted with ethyl acetate. The extract was dried with anhydrous magnesium sulfate, and then concentrated in vacuo to yield Compound 18 (2.02 g, 100%) . LC/MS (Method D): 1.21 min, [M+H]+ = 268 1H-NMR (DMSO-d6) δ: 12.58 (1H, brs), 6.58 (1H, s), 4.61 (2H, s), 4.16 (2H, t, J = 5.5 Hz), 3.82 (2H, t, J = 5.5 Hz), 1.44 (9H, s).
References:
Shionogi&Co., Ltd. EP2327704, 2011, A1 Location in patent:Page/Page column 53
3112-31-0
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1209492-73-8
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4077-76-3
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1209492-73-8
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![1H-Pyrazole-3,5-dicarboxylic acid, 1-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-, 3,5-dimethyl ester](/CAS/20200611/GIF/1209492-68-1.gif)
1209492-68-1
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![1H-Pyrazole-3,5-dicarboxylic acid, 1-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-, 3-methyl ester](/CAS/20200611/GIF/1209492-69-2.gif)
1209492-69-2
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1209492-73-8
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