6,7-Dichloro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester synthesis
- Product Name:6,7-Dichloro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester
- CAS Number:122224-58-2
- Molecular formula:C12H9Cl2NO3
- Molecular Weight:286.11
Yield:122224-58-2 63 %
Reaction Conditions:
in 1,4-dioxane;Reflux;
Steps:
Ethyl 6-fluoro-1,4-dihydroquinoline-4-one-3-carboxylate (3a).
General procedure: A mixture of aniline 1 (0.01 mol) and diethyl 2-(ethoxymethylene)malonate (0.1 mol) was taken in 20 mL of dioxane and heated and stirred at reflux for 9 h. The reaction mixture was allowed to cool at room temperature and poured in ice-cooled water. The precipitated product dried under a vacuum and recrystallized from absolute alcohol. Ethyl 6-fluoro-1,4-dihydroquinoline-4-one-3-carboxylate (3a).
References:
Dubal;Vachchharajani;Solanki;Shah [Russian Journal of General Chemistry,2022,vol. 92,# 10,p. 2161 - 2168][Zh. Obshch. Khim.,2022,vol. 92,# 10,p. 2161 - 2168]
![1,3-diethyl 2-{[(3,4-dichlorophenyl)amino]methylidene}propanedioate](/CAS/20200119/GIF/26832-89-3.gif)
26832-89-3
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