1,3-Dioxane-4-acetic acid, 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2-phenyl-, 1,1-dimethylethyl ester, (4R,6S)- synthesis
- Product Name:1,3-Dioxane-4-acetic acid, 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2-phenyl-, 1,1-dimethylethyl ester, (4R,6S)-
- CAS Number:1235588-97-2
- Molecular formula:C33H40FN3O6S
- Molecular Weight:625.75
124655-09-0
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Yield:-
Steps:
Multi-step reaction with 6 steps
1.1: 1H-imidazole; dmap / dichloromethane / 0.5 h / 20 °C
1.2: 3 h / 20 °C
2.1: acetic acid / tetrahydrofuran / 2 h / 20 °C
3.1: pyridinium p-toluenesulfonate / dichloromethane / 6 h / 20 °C
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 20 °C
5.1: potassium bromide; sodium hydrogencarbonate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite / dichloromethane / -15 - 20 °C
6.1: potassium carbonate / dimethyl sulfoxide / 1 h / 18 °C
6.2: 5 h / 60 °C
References:
KR2016/126700,2016,A
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![tert-Butyl (4R-cis)-6-[(acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate](/CAS/GIF/154026-95-6.gif)
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