3-Chloro-4-fluoro-5,6,7,8-tetrahydroisoquinolin-5-ol synthesis
- Product Name:3-Chloro-4-fluoro-5,6,7,8-tetrahydroisoquinolin-5-ol
- CAS Number:1236770-01-6
- Molecular formula:C9H9ClFNO
- Molecular Weight:201.63
17282-04-1
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Yield:-
Steps:
Multi-step reaction with 4 steps
1.1: tert.-butyl lithium / n-heptane; tetrahydrofuran / 1.25 h / -78 °C / Inert atmosphere
1.2: 3 h / -78 - -30 °C / Inert atmosphere
2.1: tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
3.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 20 °C / Inert atmosphere
4.1: platinum(IV) oxide; hydrogen / methanol / 1 h / 20 °C / 760.05 Torr / Inert atmosphere
References:
Velcicky, Juraj;Schlapbach, Achim;Heng, Richard;Revesz, Laszlo;Pflieger, Daniel;Blum, Ernst;Hawtin, Stuart;Huppertz, Christine;Feifel, Roland;Hersperger, Rene [ACS Medicinal Chemistry Letters,2018,vol. 9,# 4,p. 392 - 396]
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1236769-86-0
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1236770-01-6
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