5-Allyl-2-chloro-3-fluoroisonicotinaldehyde synthesis
- Product Name:5-Allyl-2-chloro-3-fluoroisonicotinaldehyde
- CAS Number:1236769-86-0
- Molecular formula:C9H7ClFNO
- Molecular Weight:199.61
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Yield:1236769-86-0 41%
Reaction Conditions:
Stage #1: 2-chloro-3-fluoropyridinewith tert.-butyl lithium in tetrahydrofuran;n-heptane at -78; for 1.25 h;Inert atmosphere;
Stage #2: N-formyl-N,N',N'-trimethylethylenediaminewith n-butyllithium in tetrahydrofuran;hexane;n-heptane at -78 - -30; for 3 h;Inert atmosphere;Bouveault Aldehyde Synthesis;
Stage #3: allyl bromide
References:
Velcicky, Juraj;Schlapbach, Achim;Heng, Richard;Revesz, Laszlo;Pflieger, Daniel;Blum, Ernst;Hawtin, Stuart;Huppertz, Christine;Feifel, Roland;Hersperger, Rene [ACS Medicinal Chemistry Letters,2018,vol. 9,# 4,p. 392 - 396] Location in patent:supporting information
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106-95-6
426 suppliers
$10.00/5g
1236769-86-0
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