ChemicalBook CAS DataBase List 1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid

1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid synthesis

6synthesis methods

Product Name:1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid
CAS Number:123853-39-4
Molecular formula:C16H15Cl2NO4
Molecular Weight:356.2

91189-59-2 Synthesis

91189-59-2
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$185.00/100mg

1,4-Dihydro-2,6-dimethyl-4-(2',3'-dichlorophenyl)-5-carboxy methyl-3-pyridinecarboxylic acid

123853-39-4
85 suppliers
$59.00/100mg

Yield: 99%

Reaction Conditions:

with methanesulfonic acid at 80; for 3 h;Temperature;

Steps:

1-5 Preparation of 4-(-2,3-dichlorophenyl) -1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-3-pyridinecarboxylic acid (I), its reaction formula as follows:
4-(-2,3-dichlorophenyl) -1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl ester (II)(500g, 1.35mol) was added to methanesulfonic acid (1000g),Heat to the reaction temperature of 80 ° C with stirring,And stirred at this temperature for 3h,The reaction temperature is reduced to 5-10 ° C, filtered, and the filter cake is washed with a small amount of cold methanesulfonic acid.Drying to obtain 476.2g of product (I),Yield: 99%.

References:

Shanghai Institute of Technology;Fang Yahui;Yao Lingyan CN110615757, 2019, A Location in patent:Paragraph 0040-0052