1240483-21-9 synthesis
- Product Name:1240483-21-9
- CAS Number:1240483-21-9
- Molecular formula:C30H52O4Si2
- Molecular Weight:532.9
1240483-20-8
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18162-48-6
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1240483-21-9
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Yield:1240483-21-9 95%
Reaction Conditions:
with 1H-imidazole in dichloromethane at 20; for 18 h;Inert atmosphere;
Steps:
4
Preparation of the compound XIIImidazole (528 mg, 7.7 mmoles, 2.5 eq) and TBS-Cl (536 mg, 3.5 mmoles, 1.15 eq) are added, in the above order, at room temperature to a solution of the alcohol XI (1.3 g, 3.1 mmoles) in dicbloromethane (35 mL). The formation of a white precipitate can be immediately noted, the reaction is performed under stirring at room temperature and is complete after 18 hours. To quench the reaction, a saturated solution of sodium bicarbonate (25 mL) is added, it is diluted with dichloromethane (20 mL), the phases are separated, the aqueous phase is extracted with dichloromethane, the re-combined organic phases are dried on magnesium sulphate and filtered, and lastly the solvent is removed at reduced pressure. The product is purified by means of column chromatography (hexane- AcOEt 9:1 v/v) and the pure product is obtained as a white solid with a yield of 95%.
References:
WO2010/97672,2010,A1 Location in patent:Page/Page column 20-21
18162-48-6
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