2-(2-Methoxyphenyl)-1-methyl-3-diphenylphosphino)-1H-indole synthesis
- Product Name:2-(2-Methoxyphenyl)-1-methyl-3-diphenylphosphino)-1H-indole
- CAS Number:1242759-01-8
- Molecular formula:C28H24NOP
- Molecular Weight:421.47
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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Yield: 80%
Reaction Conditions:
Stage #1:3-bromo-2-(2-methoxyphenyl)-1-methyl-1H-indole with n-butyllithium in tetrahydrofuran at -78;Inert atmosphere;
Stage #2:chloro-diphenylphosphine in tetrahydrofuran at -78 - 20;Inert atmosphere;
References:
So, Chau Ming;Chow, Wing Kin;Choy, Pui Ying;Lau, Chak Po;Kwong, Fuk Yee [Chemistry - A European Journal,2010,vol. 16,# 27,p. 7996 - 8001] Location in patent:supporting information; experimental part