tert-Butyl 7-(benzyloxy)-[1,2,4]triazolo[1,5-a]pyridine-8-carboxylate synthesis
- Product Name:tert-Butyl 7-(benzyloxy)-[1,2,4]triazolo[1,5-a]pyridine-8-carboxylate
- CAS Number:1262132-96-6
- Molecular formula:C18H19N3O3
- Molecular Weight:325.36
![tert-Butyl 7-(benzyloxy)-[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate](/CAS/20210111/GIF/1262132-95-5.gif)
1262132-95-5
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Yield:1262132-96-6 97%
Reaction Conditions:
with morpholine in ethyl acetate at 74; for 3 h;
Steps:
1.1-6
Step 1-6 The compound (200 g) obtained in step 1-5 and ethyl acetate (600 ml) were mixed, morpholine (160 ml) was added and the mixture was stirred at 74° C. for 3 hr. The mixture was allowed to cool to room temperature, and water (600 ml) was added. The aqueous layer was extracted with ethyl acetate (400 ml), the organic layers were combined and washed successively with 5% aqueous potassium hydrogensulfate solution (600 ml) and saturated brine. The organic layer was dried over sodium sulfate, filtered, and concentrated under reduced pressure to give the compound described in the above-mentioned scheme (194 g, 97%).1H-NMR (CDCl3) δ: 1.59 (9H, s), 5.28 (2H, s), 6.85 (1H, d, J=7.6 Hz), 7.33-7.46 (5H, m), 8.29 (1H, s), 8.50 (1H, d, J=7.6 Hz).
References:
US2011/77267,2011,A1 Location in patent:Page/Page column 28
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