(1R,4R)-[4-(3-Nitro-pyridin-2-ylaMino)-cyclohexyl]-carbaMic acid tert-butyl ester synthesis
- Product Name:(1R,4R)-[4-(3-Nitro-pyridin-2-ylaMino)-cyclohexyl]-carbaMic acid tert-butyl ester
- CAS Number:1289386-01-1
- Molecular formula:C16H24N4O4
- Molecular Weight:336.39
1480-87-1
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Yield:1289386-01-1 65%
Reaction Conditions:
with triethylamine in acetonitrile at 85; for 12 h;
Steps:
10.1 (1) Preparation of intermediate XI
1.5 g of 2-fluoro-3-nitropyridine,1.5 g of tert-butyl trans-(4-aminocyclohexyl)carbamate was dissolved in acetonitrile.4 mL of triethylamine was added and reacted at 85 ° C for 12 hours.The reaction solution was cooled to room temperature and concentrated under reduced pressure.Adding an aqueous solution of citric acid, heating and stirring at 30 ° C, and vacuum filtration.The filter cake was washed with a small amount of diethyl ether to give an orange solid, which was intermediate XI.The yield was 65%.
References:
CN109180702,2019,A Location in patent:Paragraph 0152; 0156; 0158; 0166-0169
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