5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride synthesis
- Product Name:5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride
- CAS Number:1289646-93-0
- Molecular formula:C10H10Cl3NO2
- Molecular Weight:282.55
1194550-56-5
32 suppliers
inquiry
1289646-93-0
90 suppliers
inquiry
Yield:1289646-93-0 97%
Reaction Conditions:
with hydrogenchloride in 1,4-dioxane;
Steps:
6; 6A
[00148] Boc-protection was used for the ring nitrogen in the intermediates 21 and 22.Compound 5 was deprotected with HC1 in dioxane to produce compound 23 in better than 97%yield. Boc-protection was introduced, using di-tert-butyl dicarbonate (1 .1 equivalent), and compound 21 was obtained in better than 95% yield. Compound 10 was coupled with compound 21 to obtain compound 22, using HATU and triethylamine in DMF. The product, compound 22, was obtained in quantitative yield, and greater than 90% purity. Deprotection with HC1 yielded the compound of Formula 12 in 97.4% yield.
References:
WO2014/18748,2014,A1 Location in patent:Paragraph 00147; 00148; 00150; 00151
10203-08-4
292 suppliers
$8.00/5g
1289646-93-0
90 suppliers
inquiry
89315-56-0
64 suppliers
$216.24/250mg
1289646-93-0
90 suppliers
inquiry
14046-52-7
8 suppliers
inquiry
1289646-93-0
90 suppliers
inquiry
1289646-72-5
24 suppliers
inquiry
1289646-93-0
90 suppliers
inquiry